Effect of haloperidol dose on iodine-123-IBZM brain SPECT imaging in schizophrenic patients.

@article{Vallabhajosula1997EffectOH,
  title={Effect of haloperidol dose on iodine-123-IBZM brain SPECT imaging in schizophrenic patients.},
  author={S. Vallabhajosula and Jack Hirschowitz and Josef Machac},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1997},
  volume={38 2},
  pages={203-7}
}
UNLABELLED Studies have suggested that antipsychotic drug therapy with haloperidol in schizophrenic patients requires an optimal dose that blocks the brain dopamine D2 receptors. We evaluated the effect of different doses of haloperidol on D2 receptor occupancy in schizophrenia. METHODS Three normal subjects and three patients with acute schizophrenia had serial brain SPECT imaging studies (every 5 min) for 3 hr following the injection of [123I]IBZM. The patients had IBZM studies off… CONTINUE READING

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