A study of spatial synchronization of the cortical biopotentials of man by multi-channel registration (leads from 48 points) made it possible to elucidate the common and specific characteristics of the action of typical (haloperidol) and atypical (clozapine) neuroleptics. The study was conducted on 10 subjects with the normal bioelectrical activity of the brain. Common for both drugs is their capacity to decrease the activity of the anterior cortical portions. They are different in that haloperidol, reducing the activity of the left hemisphere, perverts the inter-hemispherical relationships existing before its intake whereas clozapine does not change the nature of the inter-hemispherical relationships. These data may serve as the neurophysiological basis of the sedative and antipsychotic effects of typical and atypical neuroleptics.