Effect of gugulipid on bioavailability of diltiazem and propranolol.

@article{Dalvi1994EffectOG,
  title={Effect of gugulipid on bioavailability of diltiazem and propranolol.},
  author={Sudeshna S Dalvi and Vimila Nayak and S. M. Pohujani and Nagaraj Desai and Nilima A. Kshirsagar and Kailash Chand Gupta},
  journal={The Journal of the Association of Physicians of India},
  year={1994},
  volume={42 6},
  pages={454-5}
}
The effect of single oral dose of 1 gm gugulipid was studied on bioavailability of single oral dose of propranolol (40 mg) and diltiazem (60 mg) in 10 and 7 normal healthy male volunteers respectively. It was a randomised within group crossover study. Blood samples were collected at hourly intervals upto 8 hrs. Gugulipid significantly reduced (P < .01) peak plasma concentration (Cmax) and area under curve (AUC 0-8 hrs) of both the drugs in normal volunteers. Such interaction in patients… CONTINUE READING

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