Effect of guanylate cyclase-C activity on energy and glucose homeostasis.

  title={Effect of guanylate cyclase-C activity on energy and glucose homeostasis.},
  author={D P Begg and Kris A. Steinbrecher and Joram D Mul and Adam P. Chambers and Rohit Kohli and April M Haller and Mitchell Cohen and Stephen Woods and Randy J Seeley},
  volume={63 11},
Uroguanylin is a gastrointestinal hormone primarily involved in fluid and electrolyte handling. It has recently been reported that prouroguanylin, secreted postprandially, is converted to uroguanylin in the brain and activates the receptor guanylate cyclase-C (GC-C) to reduce food intake and prevent obesity. We tested central nervous system administration of two GC-C agonists and found no significant reduction of food intake. We also carefully phenotyped mice lacking the GC-C receptor and found… CONTINUE READING


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A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

The Journal of clinical investigation • 2011
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