Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy

@article{Garg1998EffectOG,
  title={Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy},
  author={S. Garg and N. Kumar and V. Bhargava and S. Prabhakar},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1998},
  volume={64}
}
To examine the effect of grapefruit juice on the bioavaiability of carbamazepine in patients with epilepsy. 
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Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.
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This widely used agent is most commonly prescribed for either seizure disorders or adjunctive pain management, and is associated with numerous clinically significant drug interactions. Expand
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CYP4503A isoenzymes in the GI tract and liver catalyze the hydroxylation of some psychiatric medications, including triazolobenzodiazepines,
Management of grapefruit-drug interactions.
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There are equally effective alternatives to these drug classes that do not have the potential to interact with grapefruit that may be substituted if a patient experiences or is at risk of a grapefruit-drug interaction. Expand
Interaction between Grapefruit Juice and Praziquantel in Humans
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The area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased and no statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life. Expand
Successful treatment of a case with concurrent ingestion of carbamazepine overdose and grapefruit juice
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A 23‐year‐old man, with a history of epilepsy, was admitted to the emergency department 2 h after ingesting 10 g CBZ with 1 L grapefruit juice and he showed signs of restlessness. Expand
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Summary: Recent findings about individual isoforms of the cytochromes P450 involved in the metabolism of phe‐nytoin (PHT) and carbamazepine (CBZ) make prediction of inhibition‐based interactionsExpand
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The findings indicate that CYP3A4 is the principal catalyst of 10,11-epoxide formation in human liver, consistent with the number of inhibitory drug interactions associated with its clinical use, interactions that result from a perturbation of CYP 3A4 catalytic activity. Expand
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TLDR
These furocoumarins are strong candidates for causative agents of grapefruit juice-mediated drug interaction, because of an inhibition potential that is equal to or stronger than the prototypical CYP3A4 inhibitor, ketoconazole, on liver microsomal testosterone 6 beta-hydroxylation. Expand
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