Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy

  title={Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy},
  author={Satish Kumar Garg and N. Kumar and Vinod kumar Bhargava and Sudesh Prabhakar},
  journal={Clinical Pharmacology \& Therapeutics},

Grapefruit juice–felodipine interaction in the elderly

Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.

Interactions between grapefruit juice and some drugs available in Australia

This booklet contains information on how to identify the different types of cannabinoids in the blood stream and how to select the good for humans and animals.

Grapefruit: the last decade acquisitions.

Carbamazepine-drug interactions: Appropriate management minimizes risk

This widely used agent is most commonly prescribed for either seizure disorders or adjunctive pain management, and is associated with numerous clinically significant drug interactions.

Grapefruit juice-drug interaction issues.

Concomitant drug and food intake create the opportunity for an interaction that may change (increase or decrease) drug benefit or toxicity.

Clinical Consequences of 3A Inhibition

CYP4503A isoenzymes in the GI tract and liver catalyze the hydroxylation of some psychiatric medications, including triazolobenzodiazepines,

Management of grapefruit-drug interactions.

There are equally effective alternatives to these drug classes that do not have the potential to interact with grapefruit that may be substituted if a patient experiences or is at risk of a grapefruit-drug interaction.

Interaction between Grapefruit Juice and Praziquantel in Humans

The area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased and no statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life.

Successful treatment of a case with concurrent ingestion of carbamazepine overdose and grapefruit juice

A 23‐year‐old man, with a history of epilepsy, was admitted to the emergency department 2 h after ingesting 10 g CBZ with 1 L grapefruit juice and he showed signs of restlessness.



Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

Current information supports the cautioning of patients about concomitant ingestion of grapefruit juice and nisoldipine, and the interaction could not be predicted from baseline pharmacokinetics with water and resulted in greater interindividual variability.

Simultaneous HPLC measurements of phenobarbitone. phenytoin and carbamazepine from plasma samples

A specific and sensitive HPLC method for simultaneously quantitating phenobarbitone, pheoytoin and carbamazepine is described and compared well with EMIT assay (syva kits).

Cytochrome P450 Isozymes and Antiepileptic Drug Interactions

  • R. Levy
  • Biology, Chemistry
  • 1995
Summary: Recent findings about individual isoforms of the cytochromes P450 involved in the metabolism of phe‐nytoin (PHT) and carbamazepine (CBZ) make prediction of inhibition‐based interactions

Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction.

These furocoumarins are strong candidates for causative agents of grapefruit juice-mediated drug interaction, because of an inhibition potential that is equal to or stronger than the prototypical CYP3A4 inhibitor, ketoconazole, on liver microsomal testosterone 6 beta-hydroxylation.