Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats.

@article{Pari2008EffectOG,
  title={Effect of grape (Vitis vinifera L.) leaf extract on alcohol induced oxidative stress in rats.},
  author={Leelevinothan Pari and Arumugam Suresh},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2008},
  volume={46 5},
  pages={1627-34}
}
Alcoholic liver disease is a major medical complication of drinking alcohol. Oxidative stress plays an important role in the development of alcohol liver disease. The present study was carried to evaluate the effect of grape leaf extract (GLEt) on antioxidant and lipid peroxidation states in liver and kidney alcohol induced toxicity. In vitro studies with DPPH* and ABTS*(+) (cation radical) showed that GLEt possesses antioxidant activity. In vivo administration of ethanol (7.9 g/kg bw/day) for… CONTINUE READING