Effect of granulocyte/macrophage colony-stimulating factor on circulating CD8+ and CD4+ T-cell responses to a multipeptide melanoma vaccine: outcome of a multicenter randomized trial.

@article{Slingluff2009EffectOG,
  title={Effect of granulocyte/macrophage colony-stimulating factor on circulating CD8+ and CD4+ T-cell responses to a multipeptide melanoma vaccine: outcome of a multicenter randomized trial.},
  author={Craig L Slingluff and Gina R. Petroni and Walter Olson and Mark Smolkin and Merrick I. Ross and Naomi Balzer Haas and William W. Grosh and Marc E. Boisvert and John Munn Kirkwood and Kimberly A Chianese-bullock},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 22},
  pages={7036-44}
}
PURPOSE Granulocyte/macrophage colony-stimulating factor (GM-CSF) administered locally together with vaccines can augment T-cell responses in animal models. Human experience has been limited to small and uncontrolled trials. Thus, a multicenter randomized phase II trial was done to determine whether local administration of GM-CSF augments immunogenicity of a multipeptide vaccine. It also assessed immunogenicity of administration in one versus two vaccine sites. EXPERIMENTAL DESIGN One hundred… CONTINUE READING

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www.aacrjournals.org Effect of GM-CSF on Response to Melanoma

  • E Jager, M Ringhoffer, HP Dienes
  • Clin Cancer Res
  • 2009

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