Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam.

Abstract

Sixty volunteers with insomnia participated in a randomized, double-blind, controlled clinical trial. After an initial six nights of placebo, 30 subjects (the abrupt-withdrawal group) received 0.5 mg of triazolam nightly for 7 to 10 nights, after which they received placebo. The other 30 subjects (the tapered-dosage group) received the same initial placebo… (More)

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Cite this paper

@article{Greenblatt1987EffectOG, title={Effect of gradual withdrawal on the rebound sleep disorder after discontinuation of triazolam.}, author={David J Greenblatt and Jerold S. Harmatz and Miguel A Zinny and Richard I. Shader}, journal={The New England journal of medicine}, year={1987}, volume={317 12}, pages={722-8} }