Effect of graded O 2 challenge on vascular and metabolic parameters

@inproceedings{Xu2010EffectOG,
  title={Effect of graded O 2 challenge on vascular and metabolic parameters},
  author={Feng Xu and Peipei Liu and Huo Lu},
  year={2010}
}
INTRODUCTION: Calibrated fMRI relies on an iso-CMRO2 challenge to obtain the calibration factor, M (1-3). Typically, the calibration experiment is performed using hypercapnia via inhalation of CO2 gas mixture. However, recent evidence suggested that CO2 may cause a suppression of neural activity by 10-15% due to acidosis in the brain parenchyma (4). Thus O2 challenge became a preferred option for the calibration experiment (3). However, the assumption that O2 challenge is iso-CMRO2 has not been… CONTINUE READING