Effect of gonococcal lipooligosaccharide variation on human monocytic cytokine profile

@article{Patrone2006EffectOG,
  title={Effect of gonococcal lipooligosaccharide variation on human monocytic cytokine profile},
  author={Julia Beth Patrone and D. C. Stein},
  journal={BMC Microbiology},
  year={2006},
  volume={7},
  pages={7 - 7}
}
BackgroundNeisseria gonorrhoeae is an obligate human pathogen that causes significant worldwide morbidity. N. gonorrhoeae expresses lipooligosaccharide (LOS), a phase variable molecule that plays an important role during pathogenesis of the organism. Alteration in the structure of gonococcal LOS correlates with altered disease presentation. In addition, LOS sialylation occurs readily in vivo, though the role of this sialylation during disease is unknown.ResultsChallenge of human monocytes with… CONTINUE READING

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