Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro.

@article{Li1993EffectOG,
  title={Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro.},
  author={Zheng Guo Li and V. A. Danis and Peter M Brooks},
  journal={Clinical and experimental rheumatology},
  year={1993},
  volume={11 2},
  pages={157-62}
}
Sex hormones have profound effects on immune responses and may influence the outcome of autoimmune diseases such as rheumatoid arthritis (RA). We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA. Peripheral blood mononuclear cells (PBMCs) were isolated from healthy male donors and male patients with RA, and were stimulated with lipopolysaccharide (LPS) in the presence of different… CONTINUE READING
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