Effect of glycosylation on cis/trans isomerization of prolines in IgA1-hinge peptide.

Abstract

The hinge region of human immunoglobulin A1 (IgA1), connecting the Fab and Fc regions, is mostly composed of Ser, Thr, and Pro (VPSTPPTPSPSTPPTPSPS); hinge peptide (HP). O-Glycans are naturally attached on only particular five Ser/Thr residues in this region. NMR was employed for analysis of the structural changes in HP upon the glycosylation, especially… (More)
DOI: 10.1021/ja9106429

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