Effect of glutaraldehyde treatment on enzyme-loaded erythrocytes.

@article{Deloach1977EffectOG,
  title={Effect of glutaraldehyde treatment on enzyme-loaded erythrocytes.},
  author={John R. Deloach and Stefan Peters and O D Pinkard and Robert Hayes Glew and G Ihler},
  journal={Biochimica et biophysica acta},
  year={1977},
  volume={496 2},
  pages={507-15}
}
In principle, enzyme-loaded erythrocytes can be used as a vehicle for enzyme replacement therapy in lysosomal storage diseases. Glutaraldehyde treatment renders these erythrocytes more resistant to lysis without inactivating the enzymes that have been entrapped inside them. Glutaraldehyde treatment does not prevent ingestion of enzyme-loaded erythrocytes by macrophages in vitro so that these cells can be used to deliver enzymes to lysosomes. In vivo, the glutaraldehyde-treated cells are quickly… CONTINUE READING

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