Effect of glutamine on methotrexate efficacy and toxicity.

@article{Rubio1998EffectOG,
  title={Effect of glutamine on methotrexate efficacy and toxicity.},
  author={Isabel T. Rubio and Y. Cao and Laura F Hutchins and Kent C. Westbrook and V S Klimberg},
  journal={Annals of surgery},
  year={1998},
  volume={227 5},
  pages={
          772-8; discussion 778-80
        }
}
OBJECTIVE To examine the effect of oral glutamine (GLN) on the efficacy and toxicity of methotrexate (MTX). SUMMARY BACKGROUND DATA The use of high-dose chemotherapy regimens is limited by the severity of their toxicities. Oral GLN has been shown to decrease the gut toxicity seen with MTX treatment while enhancing its tumoricidal effect. METHODS AND RESULTS Studies were done in laboratory rats and in breast cancer outpatients. Fischer 344 rats were randomized to 48 hours of prefeeding with… Expand
Glutamine: A novel approach to chemotherapy-induced toxicity
  • K. Gaurav, R. Goel, M. Shukla, M. Pandey
  • Medicine
  • Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • 2012
TLDR
Current data supports the usefulness of glutamine supplementation in reducing complications of chemotherapy; however, paucity of clinical trials weakens the clear interpretation of these findings. Expand
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TLDR
The available evidence suggests that glutamine supplementation may decrease the incidence and/or severity of chemotherapy-associated mucositis, irinotecan-associated diarrhea, paclitaxel-induced neuropathy, hepatic veno-occlusive disease in the setting of high dose chemotherapy and stem cell transplantation, and the cardiotoxicity that accompanies anthracycline use. Expand
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Glutamine may reduce the severity of peripheral neuropathy associated with high-dose paclitaxel; however, results from randomized, placebo-controlled clinical trials will be needed to fully assess its impact, if any. Expand
Safety and Efficacy of oral and parenteral glutamine supplementation in reducing chemotherapy induced toxicities in patients with breast cancer receiving chemotherapy: Results of interim analysis of a prospective, randomized, three arm, placebo-controlled study (NCT00772824).
TLDR
Results of the present study show that glutamine supplementation significantly reduces the GI toxicity and have a favorable safety profile, and it is further suggested that a combination of oral and parenteral glutamine may be given together for enhancement of effect. Expand
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Glutamine supplementation can attenuate loss of protein in the muscle in tumor-bearing animals and protect immune and gut-barrier function during radiochemotherapy in patients with advanced cancer. Expand
[Carboxypeptidase-G2 administration after high-dose methotrexate. Treatment and drug interactions].
TLDR
An adolescent who was diagnosed with T lymphoblastic lymphoma was receiving treatment with glutamine when the third course of methotrexate was administered and he suffered a deterioration in his renal function and the concentrations of MTX may be overestimated. Expand
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Recent studies have shown that GLN could have dichotomic actions in host versus in tumour, probably in link with glutathione metabolism, suggesting thatGLN could be used in clinical practice to increase the therapeutic index of oncological treatments. Expand
The Role of Glutamine Supplementation in Thoracic and Upper Aerodigestive Malignancies
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The use of oral gln may especially have an important role in the prevention of acute radiation toxicities, the weight loss and the need for analgesics in patients with T&UAM, especially if the treatment plan includes combined modality therapy with chemo-radiation. Expand
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The aim of this study was to investigate the status of antioxidant glutathione peroxidase (GSH-Px) during oxidative stress in blood serum of rats subjected to oral methotrexate administration at aExpand
Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia
TLDR
Parenteral glutamine appears to be feasible and safe to prevent oral mucositis in patients receiving HDMTX, and no severe adverse effects associated with glutamine administration were noted. Expand
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