Effect of glucuronidation on transport and tissue accumulation of tyrosine kinase inhibitors: consequences for the clinical management of sorafenib and regorafenib.


INTRODUCTION UDP-glucuronosyltransferases (UGTs) are a multigenic family of enzymes responsible for the glucuronidation reaction. Many therapeutic classes of drugs used in solid tumors are UGT substrates, including cancer therapies. AREAS COVERED This article describes the tyrosine kinase inhibitors (TKIs) undergoing hepatic glucuronidation; its effect on… (More)
DOI: 10.1517/17425255.2015.1030392


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