Effect of glucose on initiation and elongation rates in isolated rat pancreatic islets.

@article{Permutt1974EffectOG,
  title={Effect of glucose on initiation and elongation rates in isolated rat pancreatic islets.},
  author={M. Alan Permutt},
  journal={The Journal of biological chemistry},
  year={1974},
  volume={249 9},
  pages={2738-42}
}
Isolated rat pancreatic islets incubated in media containing glucose at 16.6 mM incorporate [3H]leucine into protein at twice the rate of islets incubated in glucose at 2.8 mu. Increased incorporation was independent of new RNA synthesis, so the effects of glucose on initiation and elongation rates were determined. The relative rates of elongation at 2.8 and 16.6 mM glucose were determined by pulsing islets in [3H]leucine for 6 min and measuring the ratio of incorporation into soluble (S) and… CONTINUE READING

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