Effect of glucosamine on interleukin-1-conditioned articular cartilage.

@article{Fenton2002EffectOG,
  title={Effect of glucosamine on interleukin-1-conditioned articular cartilage.},
  author={Jenifer I. Fenton and K A Chlebek-Brown and John P. Caron and Michael W. Orth},
  journal={Equine veterinary journal. Supplement},
  year={2002},
  volume={34},
  pages={
          219-23
        }
}
Glucosamine inhibits recombinant human interleukin-1 stimulated cartilage degradation in equine cartilage explants. Recently, recombinant equine interleukin-1 has been cloned and purified. Therefore, the objective of this study was to characterise the effects of glucosamine on indices of cartilage degradation in recombinant equine IL-1beta-stimulated equine articular cartilage explants. Cartilage discs were harvested from the weight-bearing region of the articular surface of the… Expand
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Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin-1 conditioned equine articular cartilage explant metabolism.
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The results suggests that GU+CS may prevent cartilage GAG degradation and may be more effective in preventing or treating osteoarthritis in horses than either product alone. Expand
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It is suggested that the claimed structure modifying effects of GlcN are more likely based on protection against ECM degradation than new ECM production. Expand
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Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone.
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GluNH(2) and CS act synergistically in reversing damage and promoting repair at concentrations found in plasma after oral ingestion of these agents. Expand
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