Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.

  title={Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.},
  author={Hiba Al-Hamidi and Alison A Edwards and Dionysis Douroumis and Kofi Asare-Addo and Alireza Mohajjel Nayebi and Siamak Reyhani-Rad and Javad Mahmoudi and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl
Solid state analysis showed that ibuprofen is stable under grinding conditions, but the presence of high concentration of GL in samples subjected to high grinding times caused changes in FT-IR spectrum of Ibu, which could be due to intermolecular hydrogen bond or esterification between the carboxylic acid group in the ib uprofen and hydroxylgroup in the GL.
The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets.
Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV
Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites
The spray-dried dispersions support safer and more effective delivery of multiple doses of paracetamol, leading to an acceleration of its analgesic actions and is expected to facilitate effective treatment of persistent pain-related illnesses such as osteoarthritis.
A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
Milling and co-milling are well known techniques that have potential to enhance the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first
The Influence of Fillers on Theophylline Release from Clay Matrices
The results therefore show that theophylline does not interact with MAS, and the dominant factor in controlling drug release using MAS requires interaction or intercalation with a cationic drug.
Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements
Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome


Enhancing Dissolution Rate of Carbamazepine via Cogrinding with Crospovidone and Hydroxypropylmethylcellulose
Reduced crystallinity together with a reduced particle size, enhanced deaggregation and increased wettability of the drug could be accounted for the increased dissolution from the cogrounds.
Grinding of drugs with pharmaceutical excipients at cryogenic temperatures
The effect of cryogenic grinding on the piroxicam and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry (DSC). The
Dissolution of ionizable water-insoluble drugs: the combined effect of pH and surfactant.
This model may be useful in predicting the dissolution of an ionizable water insoluble drug as a function of pH and surfactant and for establishing in vitro-in vivo correlations, IVIVC, for maintaining bioequivalence of drug products.
Comparison of the surface properties of salbutamol sulphate prepared by micronization and a supercritical fluid technique
As materials for drug delivery via the pulmonary route are rarely crystallised to provide the requirements of particle size and size distribution to reach the deep lung region (i.e. 1-5 microns),
Characterization of piroxicam crystal modifications.
The concept of dissolution efficiency
  • K. A. Khan
  • Chemistry
    The Journal of pharmacy and pharmacology
  • 1975
A further parameter suitable for the evaluation of in vitro dissolution has been suggested by Khan & Rhodes (1972), who introduced the idea of Dissolution Efficiency, defined as the area under the dissolution curve up to a certain time expressed as a percentage of the area of the rectangle described by 100% dissolutionin the sametime.
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal
Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis.
The efficacy and tolerance of oral glucosamine sulphate were tested against placebo in a prospective double-blind trial in 20 out-patients with established osteoarthrosis and significant alleviation of symptoms was associated with the use of the active drug at the prescribed dose.