Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.

  title={Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.},
  author={Hiba Al-Hamidi and Alison A Edwards and Dionysis Douroumis and Kofi Asare-Addo and Alireza Mohajjel Nayebi and Siamak Reyhani-Rad and Javad Mahmoudi and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
Piroxicam is a non-steroidal anti-inflammatory drug that is characterised by low solubility and high permeability. In order to improve the drug dissolution rate, the co-grinding method was used as an approach to prepare piroxicam co-ground in the carriers such as glucosamine hydrochloride. As, this amino sugar (glucosamine HCl) has been shown to decrease pain and improve mobility in osteoarthritis in joints, therefore, the incorporation of glucosamine in piroxicam formulations would be expected… Expand
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The concept of dissolution efficiency
  • K. A. Khan
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1975
A further parameter suitable for the evaluation of in vitro dissolution has been suggested by Khan & Rhodes (1972), who introduced the idea of Dissolution Efficiency, defined as the area under the dissolution curve up to a certain time expressed as a percentage of the area of the rectangle described by 100% dissolutionin the sametime. Expand
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