Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.

@article{AlHamidi2013EffectOG,
  title={Effect of glucosamine HCl on dissolution and solid state behaviours of piroxicam upon milling.},
  author={Hiba Al-Hamidi and Alison A Edwards and Dionysis Douroumis and Kofi Asare-Addo and Alireza Mohajjel Nayebi and Siamak Reyhani-Rad and Javad Mahmoudi and Ali Nokhodchi},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2013},
  volume={103},
  pages={
          189-99
        }
}
Piroxicam is a non-steroidal anti-inflammatory drug that is characterised by low solubility and high permeability. In order to improve the drug dissolution rate, the co-grinding method was used as an approach to prepare piroxicam co-ground in the carriers such as glucosamine hydrochloride. As, this amino sugar (glucosamine HCl) has been shown to decrease pain and improve mobility in osteoarthritis in joints, therefore, the incorporation of glucosamine in piroxicam formulations would be expected… Expand
The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl
TLDR
Solid state analysis showed that ibuprofen is stable under grinding conditions, but the presence of high concentration of GL in samples subjected to high grinding times caused changes in FT-IR spectrum of Ibu, which could be due to intermolecular hydrogen bond or esterification between the carboxylic acid group in the ib uprofen and hydroxylgroup in the GL. Expand
The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets.
TLDR
Grewia polysaccharide is highlighted as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world. Expand
The use of various organic solvents to tailor the properties of ibuprofen–glucosamine HCl solid dispersions
Ibuprofen is a Biopharmaceutical classification system class II drug that exhibits poor dissolution rate in the gastrointestinal tract. The aim of the present study is to enhance the dissolution ofExpand
Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir
The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IVExpand
Increased dissolution rates of carbamazepine – gluconolactone binary blends processed by hot melt extrusion
TLDR
A new hydrophilic carrier, d-gluconolactone (GNL), was extruded with CBZ at various molar ratios to produce granules by using hot melt extrusion (HME) processing to enhance the dissolution rate of Carbamazepine. Expand
Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions.
This work explores the use of both spray drying and d-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic chargesExpand
An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine
Abstract One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forcesExpand
Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites
TLDR
The spray-dried dispersions support safer and more effective delivery of multiple doses of paracetamol, leading to an acceleration of its analgesic actions and is expected to facilitate effective treatment of persistent pain-related illnesses such as osteoarthritis. Expand
A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
Milling and co-milling are well known techniques that have potential to enhance the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The firstExpand
The Influence of Fillers on Theophylline Release from Clay Matrices
The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices. To thisExpand
...
1
2
3
...

References

SHOWING 1-10 OF 22 REFERENCES
Enhancing Dissolution Rate of Carbamazepine via Cogrinding with Crospovidone and Hydroxypropylmethylcellulose
TLDR
Reduced crystallinity together with a reduced particle size, enhanced deaggregation and increased wettability of the drug could be accounted for the increased dissolution from the cogrounds. Expand
To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
TLDR
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand
Grinding of drugs with pharmaceutical excipients at cryogenic temperatures
The effect of cryogenic grinding on the piroxicam and its mixtures with polyvinylpyrrolidone (PVP) was studied by powder X-ray diffraction and differential scanning calorimetry (DSC). TheExpand
Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats
Abstract Gastric mucosal damage, the most common event following oral administration of NSAIDs, is due to a combination of a systemic effect and a high local drug concentration effect. It has beenExpand
Dissolution of ionizable water-insoluble drugs: the combined effect of pH and surfactant.
TLDR
This model may be useful in predicting the dissolution of an ionizable water insoluble drug as a function of pH and surfactant and for establishing in vitro-in vivo correlations, IVIVC, for maintaining bioequivalence of drug products. Expand
Comparison of the surface properties of salbutamol sulphate prepared by micronization and a supercritical fluid technique
As materials for drug delivery via the pulmonary route are rarely crystallised to provide the requirements of particle size and size distribution to reach the deep lung region (i.e. 1-5 microns),Expand
Characterization of piroxicam crystal modifications.
TLDR
Differences in dissolution rates among crystal forms of piroxicam were attributed to differences in their wettable, where highest wettability was obtained for monohydrate and the lowest for form III. Expand
The concept of dissolution efficiency
  • K. A. Khan
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1975
TLDR
A further parameter suitable for the evaluation of in vitro dissolution has been suggested by Khan & Rhodes (1972), who introduced the idea of Dissolution Efficiency, defined as the area under the dissolution curve up to a certain time expressed as a percentage of the area of the rectangle described by 100% dissolutionin the sametime. Expand
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinalExpand
The effect of pH dependent molecular conformation and dimerization phenomena of piroxicam on the drug:cyclodextrin complex stoichiometry and its chromatographic behaviour. A new specific HPLC method for piroxicam:cyclodextrin formulations.
TLDR
It was found that the pH dependent self-association phenomena, detected in both alkaline and acidic media, are the defining features for complex stoichiometry. Expand
...
1
2
3
...