Effect of gliclazide on DNA damage in human peripheral blood lymphocytes and insulinoma mouse cells.

@article{Sliwinska2006EffectOG,
  title={Effect of gliclazide on DNA damage in human peripheral blood lymphocytes and insulinoma mouse cells.},
  author={Agnieszka Sliwinska and Janusz Blasiak and J{\'o}zef Drzewoski},
  journal={Chemico-biological interactions},
  year={2006},
  volume={162 3},
  pages={259-67}
}
Type 2 diabetes mellitus is associated with increased oxidative stress. Free radicals produced during this stress may damage various cellular components. Gliclazide, a second-generation sulfonylurea, is an oral hypoglycemic drug that possesses antioxidant properties. Therefore, gliclazide may diminish the harmful consequences of oxidative stress in diabetic patients. The aim of our study was to evaluate the action of gliclazide on DNA damage and repair in normal human peripheral blood… CONTINUE READING