Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice.

@article{Lee2011EffectOG,
  title={Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice.},
  author={Jennifer L Lee and Elizabeth Martin and Gabriel Paulino and Guillaume de Lartigue and Helen E. Raybould},
  journal={Physiology & behavior},
  year={2011},
  volume={103 2},
  pages={181-7}
}
Vagal afferent neurons (VAN) express the cholecystokinin (CCK) type 1 receptor (CCK₁R) and, as predicted by the role of CCK in inducing satiation, CCK₁R⁻/⁻ mice ingest larger and longer meals. However, after a short fast, CCK₁R⁻/⁻ mice ingesting high fat (HF) diets initiate feeding earlier than wild-type mice. We hypothesized that the increased drive to eat in CCK₁R⁻/⁻ mice eating HF diet is mediated by ghrelin, a gut peptide that stimulates food intake. The decrease in time to first meal, and… CONTINUE READING