Effect of germ-line genetic variation on breast cancer survival in a population-based study.

@article{Goode2002EffectOG,
  title={Effect of germ-line genetic variation on breast cancer survival in a population-based study.},
  author={Ellen L. Goode and Alison M. Dunning and Bettina Kuschel and Catherine S. Healey and Nicholas E Day and Bruce A J Ponder and Douglas F. Easton and Paul P D Pharoah},
  journal={Cancer research},
  year={2002},
  volume={62 11},
  pages={3052-7}
}
Somatic genetic alterations in tumors are known to correlate with survival, but little is known about the prognostic significance of germ-line variation. We assessed the effect of germ-line variation on survival among women with breast cancer participating in a British population-based study. Up to 2430 cases for whom current vital status data were available were screened for BRCA1/2 mutations and genotyped for polymorphisms in 22 DNA repair, hormone metabolism, carcinogen metabolism, and other… CONTINUE READING