Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement.

@article{Otsuka2010EffectOG,
  title={Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement.},
  author={Makoto Otsuka and Hidenori Nakagawa and Atsuo Ito and William I. Higuchi},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 1},
  pages={286-92}
}
To improve the biocompatibility, inter-connective pore structure, and drug delivery ability of self-setting apatite/collagen composite cement (ACC), a three-dimensionally perforated porous apatite/collagen composite cement (TPPACC) containing 3% indomethacin (IMC) was obtained in an arranged multi-cross with 20, 40, and 60 stainless steel needlelike male… CONTINUE READING