Effect of genotypic resistance on the virological response to highly active antiretroviral therapy in cerebrospinal fluid.

@article{Cinque2001EffectOG,
  title={Effect of genotypic resistance on the virological response to highly active antiretroviral therapy in cerebrospinal fluid.},
  author={Paola Cinque and Silvia Presi and Arabella Bestetti and Chiara Pierotti and Sara Racca and Enzo Boeri and Paola Morelli and Paola Carrera and Maria Aparecida Lopes Ferrari and Adriano Lazzarin},
  journal={AIDS research and human retroviruses},
  year={2001},
  volume={17 5},
  pages={
          377-83
        }
}
Paired plasma and cerebrospinal fluid (CSF) specimens drawn from 15 HIV-infected patients with neurological disease before and after a median 6-week duration of highly active antiretroviral therapy (HAART) were studied to assess the short-term virological response of CSF and whether this can be predicted on the basis of baseline resistance mutations. After treatment, the median plasma and CSF viral load (VL) decreased by, respectively, 2.08 log10 (p = 0.0001) and 0.91 log10 copies/ml (p = 0.007… CONTINUE READING
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