Effect of genome size on AAV vector packaging.

  title={Effect of genome size on AAV vector packaging.},
  author={Zhijian Wu and Hongyan Yang and Peter Colosi},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={18 1},
Adeno-associated virus (AAV) vector genomes have been limited to 5 kilobases (kb) in length because their packaging limit was thought to be similar to the size of the parent AAV genome. Recent reports claim that significantly larger vector genomes can be packaged intact. We examined the packaged vector genomes from plasmid-encoded AAV vectors that ranged from 4.7 to 8.7 kb in length, using AAV types 2, 5, and 8 capsids. Southern blot analysis indicated that packaged AAV vector genomes never… CONTINUE READING
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