Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.

@article{Craven2015EffectOG,
  title={Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.},
  author={Brian Craven and Violeta Zaric and Abigail Martin and Coralie Mureau and Laurence John Egan},
  journal={Inflammatory bowel diseases},
  year={2015},
  volume={21 3},
  pages={
          485-95
        }
}
BACKGROUND Intestinal inflammation in inflammatory bowel diseases is driven by abnormal levels of proinflammatory cytokines, where tumor necrosis factor (TNF)-α seems to be particularly important. Chronic inflammatory signaling in the colon increases the risk of colorectal cancer, so we sought to evaluate the role of TNF-α in a mouse model of this condition. METHODS TNF mice were treated with azoxymethane/dextran sulfate sodium to induce inflammation and tumorigenesis. Etanercept was used to… CONTINUE READING