Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine

@inproceedings{Glncsr2014EffectOG,
  title={Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine},
  author={Fl{\'o}ra G{\"o}l{\"o}ncs{\'e}r and Be{\'a}ta Sperl{\'a}gh},
  booktitle={The Journal of Headache and Pain},
  year={2014}
}
Purine receptors participate in peripheral and central sensitization and are associated with migraine headache. We investigated the role of P2X7 receptor (P2X7) in a nitroglycerin (NTG)-induced mouse model of migraine. Intraperitoneal NTG injection (15 mg/kg) triggered thermal hyperalgesia in the hindpaws of wild-type C57BL/6J mice, followed by the induction of c-fos in upper cervical spinal cord and trigeminal nucleus caudalis. The effect of genetic deletion of P2X7 and the selective P2X7… CONTINUE READING

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