Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.

@article{Nicolas2012EffectOG,
  title={Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects.},
  author={J-M Nicolas and Hugues Chanteux and Maria I. De Rosa and Shikiko Watanabe and Armel Stockis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 8},
  pages={
          1466-72
        }
}
Brivaracetam (BRV) is a new high-affinity synaptic vesicle protein 2A ligand in phase III for epilepsy. Initial studies suggested that the hydroxylation of BRV into BRV-OH is supported by CYP2C8. Other metabolic routes include hydrolysis into a carboxylic acid derivative (BRV-AC), which could be further oxidized into a hydroxy acid derivative (BRV-OHAC). The aim of the present study was to investigate the effect of gemfibrozil (CYP2C9 inhibitor) and its 1-O-β-glucuronide (CYP2C8 inhibitor) on… CONTINUE READING

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