Effect of gastrin receptor blockade on gastrin and histidine decarboxylase gene expression in rats during achlorhydria.

@article{Simon1995EffectOG,
  title={Effect of gastrin receptor blockade on gastrin and histidine decarboxylase gene expression in rats during achlorhydria.},
  author={B Simon and Rolf Eissele and Małgorzata Czornik and B Swarovsky and Rudolf Arnold},
  journal={Scandinavian journal of gastroenterology},
  year={1995},
  volume={30 6},
  pages={
          503-10
        }
}
BACKGROUND Gastrin stimulates histidine decarboxylase (HDC) activity and proliferation of enterochromaffin-like (ECL) cells. Furthermore, it has been suggested that gastrin controls HDC gene expression. We therefore analysed the effect of gastrin receptor blockade by PD 136 450 (CAM 1189) on HDC gene expression. The influence of PD 136 450 on gastrin, somatostatin, and chromogranin A was also evaluated. METHODS Gene expression of HDC, gastrin, somatostatin, and chromogranin A (CgA) was… CONTINUE READING