Effect of gastric vagal denervation on inhibition of acid secretion by secretin

@article{Brooks2005EffectOG,
  title={Effect of gastric vagal denervation on inhibition of acid secretion by secretin},
  author={A. M. Brooks and G. Stening and M. Grossman},
  journal={The American Journal of Digestive Diseases},
  year={2005},
  volume={16},
  pages={193-200}
}
In dogs with vagally innervated gastric pouches and gastric fistulas, acid secretion was stimulated by intravenous administration of Urecholine, 0.025 and 0.1 (mg/kg)/hr; of pentagastrin, 4 (µg/kg)/hr; or by feeding a meal of liver and bone dust, 25 g/kg. Acid secretion elicited by these stimulants was significantly inhibited (P<0.05 to 0.001) by intravenous infusion of secretin, 2 (units/kg)/hr. With Urecholine, 0.1 (mg/kg)/hr, comparable inhibition resulted from endogenous duodenal… Expand
Comparison of vasoactive intestinal peptide (VIP) and secretin in gastric secretion and mucosal blood flow
Multiple actions of secretin in the human body.

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