Effect of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on haemato-biochemical parameters and liver enzyme activities in Wistar rats

  title={Effect of garlic (Allium sativum) and ginger (Zingiber officinale) extracts on haemato-biochemical parameters and liver enzyme activities in Wistar rats},
  author={Joshua Adamu Tende and Joseph Olusegun Ayo and Aisha Mohammed and Abdulkadir Umar Zezi},
  journal={International Journal of Nutrition and Food Sciences},
  • J. Tende, J. Ayo, A. Zezi
  • Published 19 August 2014
  • Medicine
  • International Journal of Nutrition and Food Sciences
The study was designed to investigate the separate and combined effects of garlic (Allium sativum) and ginger (Zingiber officinale) on haemato-biochemical parameters and liver enzymes activities in Wistar rats. Rats were assigned into the following groups: Group 1: (Control group 1 ml of distilled water); Group 2: (20 mg/kg of garlic); Group 3: (40 mg/kg of garlic); Group 4: (20 mg/kg of ginger); Group 5: (40 mg/kg of ginger); Group 6: (garlic 10 and ginger 10 mg/kg); Group 7: (garlic 20 and… 

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  • R. Sujatha, L. Srinivas
  • Biology, Chemistry
    Toxicology in vitro : an international journal published in association with BIBRA
  • 1995
[New pharmacological activities of garlic and its constituents].
  • H. Sumiyoshi
  • Biology
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • 1997
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