Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor.

@article{Toledo2005EffectOG,
  title={Effect of ganglioside and tetraspanins in microdomains on interaction of integrins with fibroblast growth factor receptor.},
  author={Marcos Sergio Toledo and Erika Suzuki and Kazuko Handa and Sen-itiroh Hakomori},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 16},
  pages={16227-34}
}
The functional interaction ("cross-talk") of integrins with growth factor receptors has become increasingly clear as a basic mechanism in cell biology, defining cell growth, adhesion, and motility. However, no studies have addressed the microdomains in which such interaction takes place nor the effect of gangliosides and tetraspanins (TSPs) on such interaction. Growth of human embryonal WI38 fibroblasts is highly dependent on fibroblast growth factor (FGF) and its receptor (FGFR), stably… CONTINUE READING

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