Effect of gammahydroxybutyrate on intracranial pressure, mean systemic arterial pressure and cerebral perfusion pressure in experimentally induced brain oedema of the rat.

Abstract

The effect of gammahydroxybutyrate (GHB) on ICP, systemic arterial pressure and cerebral perfusion pressure in the experimentally induced brain oedema of the rat was examined. 400 mg/kg GHB reduced significantly ICP (11.74 +/- 1.20 mm Hg; control: 16.20 +/- 8.89 mm Hg; p less than 0.01) while increasing mean systemic arterial pressure (109.89 +/- 6.35 mm Hg… (More)

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@article{Plangger1990EffectOG, title={Effect of gammahydroxybutyrate on intracranial pressure, mean systemic arterial pressure and cerebral perfusion pressure in experimentally induced brain oedema of the rat.}, author={Clemens Plangger}, journal={Zentralblatt fur Neurochirurgie}, year={1990}, volume={51 1}, pages={24-33} }