Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.

@article{Surgucheva2003EffectOG,
  title={Effect of gamma-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells.},
  author={Irina G. Surgucheva and Jeremy M. Sivak and Mary Elizabeth Fini and Robert E. Palazzo and Andrei P. Surguchov},
  journal={Archives of biochemistry and biophysics},
  year={2003},
  volume={410 1},
  pages={167-76}
}
gamma-Synuclein is a small cytoplasmic protein implicated in neurodegenerative diseases and cancer. However, the mechanism of its involvement in diseases is not clear. We studied the role of gamma-synuclein in the regulation of matrix metalloproteinases in retinoblastoma cell culture. Matrix metalloproteinases play important roles in the remodeling of extracellular matrix implicated in tumor progression and in the neurodegenerative diseases. Western blot and zymography data demonstrated a… CONTINUE READING
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