Effect of gamma irradiation on human cortical bone transplants contaminated with enveloped and non-enveloped viruses.

@article{Pruss2002EffectOG,
  title={Effect of gamma irradiation on human cortical bone transplants contaminated with enveloped and non-enveloped viruses.},
  author={Axel Pruss and Moujahed Kao and Uwe Gohs and Juergen Koscielny and R{\"u}diger von Versen and Georg Pauli},
  journal={Biologicals : journal of the International Association of Biological Standardization},
  year={2002},
  volume={30 2},
  pages={125-33}
}
In the production of bone grafts intended for transplantation, basic safety measures to avoid the transmission of pathogens are selection and serological screening of donors for markers of virus infections. As an additional safety tool we investigated the effect of gamma irradiation on the sterility of human bone diaphysis transplants and evaluated its impact on the virus safety of transplants. Model viruses were included in the study to determine the dose necessary to achieve a reduction… CONTINUE READING

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