Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice

@article{BadieMahdavi2005EffectOG,
  title={Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice},
  author={Hedieh Badie-Mahdavi and M. Margarita Behrens and Julius Rebek and Tam{\'a}s B{\'a}rtfai},
  journal={Neuropeptides},
  year={2005},
  volume={39},
  pages={249-251}
}
Galanin protects against intracellular amyloid toxicity in human primary neurons.
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The results show that galanin is protective against intracellular Abeta cytotoxicity and all of the above insults at sub-nanomolar physiological concentrations, providing a potential drug target for therapy or prevention of neurodegenerative diseases, including AD.
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This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors inThe hippocampus.
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The present review summarizes the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer’s disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
Galanin – 25 years with a multitalented neuropeptide
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The present review summarizes the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer’s disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
Galanin, galanin receptors, and drug targets.
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The current data which constitute the basis of targeting GalR1, GalR2, and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors are summarized.
Galanin - ReadingSample
TLDR
This chapter summarizes the current data which constitute the basis of targeting GalR1, GalR2, and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer’s disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
K. Mitsukawa, X. Lu, and T. Bartfai
TLDR
This chapter summarizes the current data which constitute the basis of targeting GalR1, GalR2, and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzhei- mer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.
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References

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Galanin Modulation of Seizures and Seizure Modulation of Hippocampal Galanin in Animal Models of Status Epilepticus
TLDR
It is suggested that hippocampal galanin acts as an endogenous anticonvulsant via galan in an animal model of status epilepticus and may contribute to the maintenance of seizure activity, whereas the increase of Galanin concentration and the appearance of galanIn-immunoreactive neurons may favor the cessation of SSSE.
Galanin Inhibits Performance on Rodent Memory Tasks
TLDR
Nonpeptide, bioavailable, subtype‐selective galanin receptor antagonists may provide tools to test the hypothesis that antagonism of endogenous Galanin, which is overexpressed in the basal forebrain in Alzheimer's patients, can contribute to the alleviation of the cognitive deficits associated with Alzheimer's disease.
Galanin Receptor Antagonist M40 Blocks Galanin-Induced Choice Accuracy Deficits on a Delayed-Nonmatching-to-Position Task
TLDR
M40 appears to be an effective galanin antagonist in a rodent memory paradigm, indicating that this compound may prove useful in investigating the role of endogenous Galanin in learning and memory.
Pharmacological evidence supporting a role for galanin in cognition and affect
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The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal
TLDR
It is suggested that galanin normally acts to counteract opiate withdrawal and that small molecule Galanin agonists could be effective in diminishing the physical signs of withdrawal.
Anticonvulsant activity of a nonpeptide galanin receptor agonist
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TLDR
Findings introduce a systemically active nonpeptide galanin agonist anticonvulsant through this receptor subtype.
Effects of galanin on 5-HT neurons in the rat CNS.
Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests.
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
The present work uses the tripeptidomimetic galnon and displays its presumed pharmacophores on a rigid molecular scaffold and provides an example of a systemically active compound based on a scaffold that mimics protein surfaces.
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