Effect of galactooligosaccharides on calcium absorption and preventing bone loss in ovariectomized rats.

  title={Effect of galactooligosaccharides on calcium absorption and preventing bone loss in ovariectomized rats.},
  author={Osamu Chonan and K. Matsumoto and Masaaki Watanuki},
  journal={Bioscience, biotechnology, and biochemistry},
  volume={59 2},
The effects of galactooligosaccharides (GOS), a mixture of galactosyl oligosaccharides formed from lactose by the transgalactosyl reaction of beta-D-galactosidase derived from Bacillus circulans, on calcium absorption and prevention of bone loss were examined in ovariectomized (OVX) Wistar rats. Rats fed on a diet containing GOS absorbed calcium more efficiently than those on the control diet after 8-10 days and 18-20 days, and the bone (femur and tibia) ash weight and tibia calcium content of… 

Galactooligosaccharides improve mineral absorption and bone properties in growing rats through gut fermentation.

Regression modeling showed that GOS benefited calcium and magnesium utilization and vBMD through decreased cecal pH, increased cecAL wall and content weight, and increased proportion of bifidobacteria.

Galacto-oligosaccharides: Prebiotic Effects on Calcium Absorption and Bone Health

Dairy supplementation with GOS in rats has been associated with improved bone mineral content during growth, reduced losses of BMC and bone mineral density after ovariectomy, and increased cecal content weight and preliminary results in adolescents show that GOS increases fractional calcium absorption.

Improving Effect of Feeding with a Phosphorylated Guar Gum Hydrolysate on Calcium Absorption Impaired by Ovariectomy in Rats

The results indicate that P-GGH may be useful for preventing the reduction of intestinal calcium absorption and bone in the condition of estrogen deficiency.

Role of Activity of Gastrointestinal Microflora in Absorption of Calcium and Magnesium in Rats Fed β1-4 Linked Galactooligosaccharides

It is suggested that the action of intestinal bacteria is necessary for the effects of GOS, and the decrease in cecal pH in rats fed GOS was suppressed by neomycin-feeding.

Running head Disaccharides and mineral absorption Authors

OBJECTIVE: We examined the effects of feeding nondigestible disaccharides, difructose anhydride III (DFAIII), maltitol, melibiose and cellobiose on calcium, magnesium and iron absorption in

Effect of a Phosphorylated Guar Gum Hydrolysate on Increased Calcium Solubilization and the Promotion of Calcium Absorption in Rats

Results indicate that P-GGH may inhibit calcium phosphate formation in the lower part of the small intestine, and thus increase calcium absorption.

Mannitol evaluated mineral absorption and bone retention in ovariectomized rats

Ca and Mg absorption and their retention were improved by cecal fermentation of mannitol in ovariectomized rats, and mineral absorption and femoral mineral was significantly increased byMannitol feeding.

Supplemental feeding of difructose anhydride III restores calcium absorption impaired by ovariectomy in rats.

In conclusion, ovarian hormone deficiency impaired Ca absorption, but the reduction of Ca absorption was restored by feeding DFAIII.