Effect of galactofucan sulfate of a brown seaweed on induced hepatotoxicity in rats, sodium pentobarbital-induced sleep, and anti-inflammatory activity

Abstract

This study was designed to characterize the chemical composition, anti-oxidant activity, anti-inflammatory, and hepatoprotective effect of the polysaccharide a galactofucan sulfate (GFS) from brown seaweed Lobophora variegata. Chemical characterization was performed by several chemical methods, high-pressure liquid chromatography (HPLC), nuclear magnetic resonance (NMR) (1H, 13C, heteronuclear multiple quantum correlation (HMQC), and 1H-1H COSY), and infrared spectroscopies. The results showed an acidic polysaccharide with a high level of sulfated fucose and galactose. GFS displayed anti-oxidant effects acting directly on the free radicals. Pretreatment with fucans in mice induced by carbon tetrachloride (CCl4) administration resulted in a significantly inhibited increase in the blood enzymatic activities and bilirubin level. Administration of GFS (75 mg kg−1) reduced (p < 0.01) the activities of enzymes. This was shown by assessment of hepatic markers alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamil transferase (γ-GT), and bilirubin reduction in serum. Histological analysis of the liver confirmed the effects of fucans on hepatoprotection. This fucan affects time of sodium pentobarbital-induced sleep, also demonstrating its effect on hepatic recuperation.

DOI: 10.1007/s10811-015-0698-y

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@article{Castro2015EffectOG, title={Effect of galactofucan sulfate of a brown seaweed on induced hepatotoxicity in rats, sodium pentobarbital-induced sleep, and anti-inflammatory activity}, author={Luiza Sheyla Evenni Porf{\'i}rio Will Castro and Allisson Jhonatan Gomes Castro and Marilia da Silva Nascimento Santos and Thuane de Sousa Pinheiro and Kahena de Quevedo Florentin and Luciana Guimaraes Alves and Eliane Marinho Soriano and Renata Mendonça Ara{\'u}jo and Edda Lisboa Leite}, journal={Journal of Applied Phycology}, year={2015}, volume={28}, pages={2005-2017} }