Effect of gadolinium on the ryanodine receptor/sarcoplasmic reticulum calcium release channel of skeletal muscle.

@article{Srkzi2005EffectOG,
  title={Effect of gadolinium on the ryanodine receptor/sarcoplasmic reticulum calcium release channel of skeletal muscle.},
  author={S{\'a}ndor S{\'a}rk{\"o}zi and Csaba Szegedi and Bal{\'a}zs Andr{\'a}s Luk{\'a}cs and Michel Ronjat and Istv{\'a}n J{\'o}na},
  journal={The FEBS journal},
  year={2005},
  volume={272 2},
  pages={
          464-71
        }
}
The effect of gadolinium ions on the sarcoplasmic reticulum (SR) calcium release channel/ryanodine receptor (RyR1) was studied using heavy SR (HSR) vesicles and RyR1 isolated from rabbit fast twitch muscle. In the [(3)H]ryanodine binding assay, 5 microM Gd(3+) increased the K(d) of the [(3)H]ryanodine binding of the vesicles from 33.8 nM to 45.6 nM while B(max), referring to the binding capacity, was not affected significantly. In the presence of 18 nM[(3)H]ryanodine and 100 microM free Ca(2… CONTINUE READING
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