The urinary excretion of prostaglandins (PG) E2 and F2 alpha, which reflects the renal synthesis of these substances, was evaluated by radioimmunoassay before and after an i.v. injection of furosemide in 10 normal subjects and in 10 patients with essential hypertension. In most normal subjects, urinary PGE2 increased after furosemide injection, whereas PGF2… (More)
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