Effect of furosemide on GABAA-induced 36Cl transport and Cl--ATPase activity in synaptic membranes of carp brain (Cyprinus carpio L.)

We studied the effect of furosemide on GABAA-induced 36Cl transport and GABAA-induced Cl--ATPase activity in synaptic membranes of fish brain. At physiological pH 7.4, GABA (0.1–100 µM) stimulated 36Cl influx in synaptoneurosomes and Cl--ATPase activity in synaptic membranes. Furosemide (0.1–0.5 mM) removed the activating effect of the mediator on chloride… CONTINUE READING