Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.

@article{Hoshi1988EffectOF,
  title={Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.},
  author={Toshinori Hoshi and Sharon Garber and Richard W. Aldrich},
  journal={Science},
  year={1988},
  volume={240 4859},
  pages={1652-5}
}
Forskolin is commonly used to stimulate adenylate cyclase in the study of modulation of ion channels and other proteins by adenosine 3',5'-monophosphate (cAMP)-dependent second messenger systems. In addition to its action on adenylate cyclase, forskolin directly alters the gating of a single class of voltage-dependent potassium channels from a clonal pheochromocytoma (PC12) cell line. This alteration occurred in isolated cell-free patches independent of soluble cytoplasmic enzymes. The effect… CONTINUE READING