Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.

  title={Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.},
  author={Hiromu Kondo and Takashi Watanabe and Shigeharu Yokohama and Jun Watanabe},
  journal={Biopharmaceutics & drug disposition},
  volume={24 4},
We investigated the gastrointestinal transit of liquids, as well as various gastric pH profiles, in fed cynomolgus monkeys. Twelve grams of a biscuit-type solid food were provided 1 h before the test. The acetaminophen method was used to determine the gastric half-emptying time (t(50%)), which provided an estimate of the gastric emptying rate. The gastric emptying rate of liquids was significantly reduced after food intake in monkeys. The mean t(50%) value was 143.5 min and comparable to that… CONTINUE READING


Publications citing this paper.
Showing 1-8 of 8 extracted citations

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2014
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…