Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.

@article{Kondo2003EffectOF,
  title={Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys.},
  author={Hiromu Kondo and Takashi Watanabe and Shigeharu Yokohama and Jun Watanabe},
  journal={Biopharmaceutics & drug disposition},
  year={2003},
  volume={24 4},
  pages={141-51}
}
We investigated the gastrointestinal transit of liquids, as well as various gastric pH profiles, in fed cynomolgus monkeys. Twelve grams of a biscuit-type solid food were provided 1 h before the test. The acetaminophen method was used to determine the gastric half-emptying time (t(50%)), which provided an estimate of the gastric emptying rate. The gastric emptying rate of liquids was significantly reduced after food intake in monkeys. The mean t(50%) value was 143.5 min and comparable to that… CONTINUE READING

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