Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.

@article{Gao2011EffectOF,
  title={Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.},
  author={Yonglin Gao and Chunmei Li and Jingyu Shen and Huaxian Yin and Xiulin An and Haizhu Jin},
  journal={Journal of food science},
  year={2011},
  volume={76 6},
  pages={
          T125-9
        }
}
UNLABELLED Tartrazine is an artificial azo dye commonly used in human food and pharmaceutical products. The present study was conducted to evaluate the toxic effect of tartrazine on the learning and memory functions in mice and rats. Animals were administered different doses of tartrazine for a period of 30 d and were evaluated by open-field test, step-through test, and Morris water maze test, respectively. Furthermore, the biomarkers of the oxidative stress and pathohistology were also… Expand
Tartrazine induced neurobiochemical alterations in rat brain sub-regions.
TLDR
It may be concluded that the ADI levels of food azo dyes adversely affect and alter biochemical markers of brain tissue and cause oxidative damage. Expand
Toxic Effects of Food azo dye Tartrazine on the Brain of Young Male Albino Rats: Role of Oxidative Stress
TLDR
Tartrazine toxicity induced severe brain damage in young male albino rats in the form of affection of the general architecture of the brain associated with increased oxidative stress and consumption of foods containing food colorant tartrazine should be restricted especially for children. Expand
THE ALLEVIATIVE EFFECT OF THYMOQUINONE ON CEREBELLAR INJURY INDUCED BY FOOD AZO DYE IN RATS
Background: Tartrazine (Tz) is one of the most commonly used food additive and synthetic color that is added to food for attracting the consumers' vision. However, it might cause many toxic effectsExpand
QUERCETIN NANOPARTICLES REPRESSED LIVER AND BRAIN TOXICITIES INDUCED BY TARTRAZINE IN RATS
Tartrazine (TZ) is an azobenzene artificial yellow dye for foods, drugs, and cosmetics. Quercetin is member of the flavonoid family. The current study investigated the protective effect of quercetinExpand
Acute Toxicity of Food additives Tartrazine and carmoisine on white male Mice
This study was conducted to evaluate the acute toxicity by measures median lethal dose of two different types of Food additives; tartrazine (E102) and carmoisine (E122) in the white male mice. InExpand
Oxidative Stress by Tartrazine in the Testis of Wistar Rats
The aim is to study the effect of Tartrazine (E102) - synthetic food colour - on the antioxidant status of testis of Wistar rats. Twelve male Wistar rats were grouped into 2 groups of six each -Expand
Antioxidant and modulatory effect of melatonin on hepatotoxicity and oxidative stress induced by Orange Yellow S in male rats.
Many azo dye derivatives are used as food colorants which cause cytotoxic effects. In recent years, a new trend to use antioxidants to neutralise the suspected effects of food additives has evolved.Expand
Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
TLDR
Perinatal exposure to TZ within an adequate daily intake range induced oxidative stress and neurobehavioral and hematological alterations in mice offspring, and consuming foods containing TZ during pregnancy and lactation warrants public awareness. Expand
Using vitamin E to prevent the impairment in behavioral test, cell loss and dendrite changes in medial prefrontal cortex induced by tartrazine in rats.
TLDR
A high dose of tartrazine may defect the visual memory, mPFC structure, the spatial memory and also cause dendrite changes, while concomitant treatment of the rats with vitamin E plus Tartrazine prevented the above-mentioned changes. Expand
Comparative Study of Some Natural and Artificial Food Coloring Agents on Hyperactivity, Learning and Memory Performance in Weanling Rats
Color additives are used in a wide variety of foods, Food azo-colours tartrazine (Tar) is one of the most widely used artificial foods, drugs and cosmetic yellow dyes, its E number is E102 whileExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats.
TLDR
It is concluded that tartrazine and carmoisine affect adversely and alter biochemical markers in vital organs e.g. liver and kidney not only at higher doses but also at low doses. Expand
Prolonged use of the food dye tartrazine (FD&C yellow no 5) and its effects on the gastric mucosa of Wistar rats.
TLDR
There was a significant increase in the number of lymphocytes and eosinophils of the gastric antrum mucosa and no carcinogenetic changes in any gastric area were observed during the study. Expand
Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice.
TLDR
The dose levels of tartrazine in the present study produced a few adverse effects on neurobehavioral parameters throughout generations in mice. Expand
Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet.
  • Toyohito Tanaka
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2006
TLDR
The dose level of tartrazine in the present study produced a few adverse effects in neurobehavioural parameters during the lactation period in mice, but the high-dose level were in excess of the ADI of Tartrazine, and the actual dietary intake of tartazine is presumed to be much lower. Expand
7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety
TLDR
The clear anxiolytic-like action of the Nitric oxide synthase inhibitor in four different models shows that nitric oxide is involved in the process of anxiety and that NOS could be a new target in developing anxio-lytic drugs. Expand
Risk Assessment for the Combinational Effects of Food Color Additives: Neural Progenitor Cells and Hippocampal Neurogenesis
TLDR
Evidence indicates that single and combination use of most tar food colors may be safe with respect to risk using developmental NPC and adult hippocampal neurogenesis, however, the response to excessively high dose combination of Y4 and B1 is suggestive of synergistic effects to suppress proliferation of NPC in adult hippocampus. Expand
Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat.
TLDR
Feeding a PR diet decreased the accumulation of lead and decreased Pb-induced learning and memory deficits in developing rats, and the mechanisms might be related to the anti-oxidative effects and large amount of GABA in PR. Expand
Age‐Dependent Cognitive and Behavioral Deficits After Kainic Acid Seizures
TLDR
Age-related behavioral and cognitive deficits after KA-induced seizures suggest Pubescents and adults had alterations in learning, memory, exploratory behavior, and response to handling, whereas younger animals had no obvious behavioral or cognitive deficits. Expand
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.
  • Vandana Panda, S. Naik
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2008
TLDR
The present findings have demonstrated that the cardioprotective effects of GBP in ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation of membrane. Expand
Reproductive and neurobehavioural toxicity study of erythrosine administered to mice in the diet.
  • T. Tanaka
  • Medicine, Biology
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2001
TLDR
The dose level of erythrosine in the present study produced few adverse effects in reproductive and neurobehavioural parameters in mice and in behavioural developmental parameters, several parameters were significantly changed in the high-dose group. Expand
...
1
2
3
4
...