Effect of food and antacid on absorption of orally administered ticlopidine hydrochloride.

@article{Shah1990EffectOF,
  title={Effect of food and antacid on absorption of orally administered ticlopidine hydrochloride.},
  author={Jatan C. Shah and A Fratis and David L. Ellis and Shigeto Murakami and Philip Teitelbaum},
  journal={Journal of clinical pharmacology},
  year={1990},
  volume={30 8},
  pages={733-6}
}
Ticlopidine is a potent inhibitor of platelet aggregation. Absorption of ticlopidine after oral dosing is rapid and complete. Ticlopidine is extensively metabolized with a relative minor component of unchanged ticlopidine in plasma. The randomized crossover study described here was undertaken to examine the effect of food and antacid on the oral bioavailability of a single dose of ticlopidine (250 mg) in normal volunteers. After postprandial treatment the rate and extent of absorption of… CONTINUE READING