Effect of fluoride on cardiopulmonary function and release of eicosanoids in pigs.

@article{Dodam1995EffectOF,
  title={Effect of fluoride on cardiopulmonary function and release of eicosanoids in pigs.},
  author={John R. Dodam and Nathan W. Olson},
  journal={Journal of applied physiology},
  year={1995},
  volume={78 2},
  pages={
          569-77
        }
}
Fluoroaluminates are believed to stimulate guanine nucleotide-binding (G) proteins, leading to activation of effector enzymes and release of vasoactive mediators. As a model for G protein-induced cardiopulmonary dysfunction, we infused NaF (0.9 M in 0.9% NaCl at 15 microliters.kg-1.min-1 for 3 h i.v.) in the presence (n = 8) and absence (n = 4) of AlCl3 (0.6 microgram.kg-1.min-1) into pigs anesthetized with pentobarbital sodium. NaF, with or without AlCl3, induced progressive deterioration of… CONTINUE READING
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