Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells.

@article{Liao2017EffectOF,
  title={Effect of fluoride exposure on mRNA expression of cav1.2 and calcium signal pathway apoptosis regulators in PC12 cells.},
  author={Qiuxia Liao and R. Zhang and X. Wang and Weiwei Nian and Lulu Ke and W. Ouyang and Z. Zhang},
  journal={Environmental toxicology and pharmacology},
  year={2017},
  volume={54},
  pages={
          74-79
        }
}
  • Qiuxia Liao, R. Zhang, +4 authors Z. Zhang
  • Published 2017
  • Chemistry, Medicine
  • Environmental toxicology and pharmacology
  • This study investigated the effects of fluoride exposure on the mRNA expression of Cav1.2 calcium signaling pathway and apoptosis regulatory molecules in PC12 cells. The viability of PC12 cell receiving high fluoride (5.0mM) and low fluoride (0.5mM) alone or fluoride combined with L-type calcium channel (LTCC) agonist/inhibitor (5umol/L FPL6417/2umol/L nifedipine) was detected using cell counting kit-8 at different time points (2, 4, 6, 8, 12, 10, and 24h). Changes in the cell configuration… CONTINUE READING
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