Effect of fluconazole on the disposition of phenytoin.

  title={Effect of fluconazole on the disposition of phenytoin.},
  author={Robert Alexander Blum and John Wilton and Dianne M Hilligoss and Mark J Gardner and E B Henry and Newt Harrison and Jerome J. Schentag},
  journal={Clinical pharmacology and therapeutics},
  volume={49 4},
In a randomized, placebo-controlled, parallel study, phenytoin was given in the presence and absence of fluconazole. Twenty healthy male subjects received phenytoin, 200 mg orally, on study days 1 to 3 and 18 to 20 and 250 mg intravenously on study days 4 and 21. Ten subjects received fluconazole, 200 mg orally, and 10 received placebo daily on study days 8 to 21. Serial blood samples were collected during a 24-hour period after the intravenous phenytoin dose. Fluconazole trough concentrations… CONTINUE READING

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