Effect of flavonoids on cell cycle progression in prostate cancer cells.

@article{Kobayashi2002EffectOF,
  title={Effect of flavonoids on cell cycle progression in prostate cancer cells.},
  author={Takashi Kobayashi and Teruhiro Nakata and Takejiro Kuzumaki},
  journal={Cancer letters},
  year={2002},
  volume={176 1},
  pages={17-23}
}
The effect of some flavonoids, which are components of fruits, vegetables, and peas, on the cell cycle progression of human LNCaP prostate cancer cells has been investigated in this study. Genistein arrested the cell cycle at the G2/M phases, which is attributed to the suppression of cyclin B expression. In addition, genistein induced the cyclin-dependent kinase inhibitor p21, which does not depend on p53 activation. Apigenin and luteolin also increased p21 levels, but quercetin did not… CONTINUE READING
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