Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.

  title={Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.},
  author={Karen Anne O'Leary and Sonia de Pascual-Teresa and Paul W. Needs and Y Y Bao and Nora M O'brien and Gary Williamson},
  journal={Mutation research},
  volume={551 1-2},
Cyclooxygenase-2 (COX-2)-catalysed synthesis of prostaglandin E2 plays a key role in inflammation and its associated diseases, such as cancer and cardiovascular disease. There are numerous reports demonstrating that flavonoids inhibit COX-2 activity. However, transcriptional regulation of COX-2 can also be important. Nobiletin, amentoflavone, quercetin, quercetin penta-acetate, flavone, resveratrol, apigenin, chrysin, kaempferol, galangin, and genistein have been reported to modulate COX-2… CONTINUE READING


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