Effect of five dietary antimutagens on the genotoxicity of six mutagens in the microscreen prophage‐induction assay

@article{Cabrera2000EffectOF,
  title={Effect of five dietary antimutagens on the genotoxicity of six mutagens in the microscreen prophage‐induction assay},
  author={G. Cabrera},
  journal={Environmental and Molecular Mutagenesis},
  year={2000},
  volume={36}
}
  • G. Cabrera
  • Published 2000
  • Biology, Medicine
  • Environmental and Molecular Mutagenesis
Dietary antimutagens have been studied extensively in the last two decades, using mainly bacterial and mammalian cells. These studies have shown that certain dietary antimutagens, acting individually or as mixtures, are useful in counteracting the effects of certain mutagens and/or carcinogens to which humans are commonly exposed. However, there are some inconsistencies among publications using different bioassays. The general purpose of the research presented here was to conduct a comparative… 
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Methods Citations
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23 Citations

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References

SHOWING 1-10 OF 46 REFERENCES
Antimutagens as cancer chemopreventive agents in the diet.
TLDR
If antimutagenic effects are to have any impact on human disease, it is essential that they are specifically directed against the most common mutagens in daily life, so that combinations of antimutagens will probably be necessary.
Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action.
TLDR
Synergism of some vitamins activity, both with other vitamins and non-vitamin substances, is of particular interest because clarifying some of their mechanisms of action could be important for understanding the functions of the defense systems.
In vitro investigation of toxaphene genotoxicity in S. typhimurium and Chinese hamster V79 lung fibroblasts.
TLDR
While toxaphene is a weak, direct-acting mutagen in the Ames Salmonella Test, convincing evidence of dose-dependent SCE induction and mutagenicity at the HGPRT gene locus could not be demonstrated in V79 cells.
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.
TLDR
Co-injection of inhibitor and AFB1 into trout embryos established that CHL was more effective than chlorophyll a in reducing AFB1-DNA adducts 2 weeks after injection, and liver tumors after 1 year.
Induction of prophage lambda by chlorinated pesticides.
TLDR
Comparisons with mutagenesis data in Salmonella indicated that the Microscreen assay detected as genotoxic each of the pesticides that were mutagenic inSalmonella; moreover, it detected 2 additional carcinogens (chlordane and lindane) that were not mutagenics in the Salmoneella assay.
Antimutagenicity profiles for some model compounds.
TLDR
Activity profiles are useful for the assessment of the available antimutagenesis data by providing rapid visualization of considerable dose information and experimental results.
Performance of 133 compounds in the lambda prophage induction endpoint of the Microscreen assay and a comparison with S. typhimurium mutagenicity and rodent carcinogenicity assays.
TLDR
The Microscreen assay was able to detect halogenated compounds better than the S. typhimurium assay, and should prove useful in complex mixture fractionation, or in other situations where sample size is limiting.
Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli.
TLDR
The intra- and interlaboratory reproducibility of the Salmonella assay with regard to the overall judgment of mutagenic or nonmutagenic was good, but the results in the E coli strain exhibited a high degree of variability between laboratories.
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.
TLDR
It is concluded that the in vitro antimutagenic activity of CHL towards BP involves accelerated degradation of the ultimate carcinogen, with inhibition of carcinogen activation occurring only at high CHL concentrations.
Induction of prophage lambda by chlorinated organics: Detection of some single‐species/single‐site carcinogens
TLDR
The prophage‐induction (or other SOS) assay may be useful in identifying some genotoxic chlorinated carcinogens that induce DNA damage that does not revert the standard Salmonella tester strains.
...
1
2
3
4
5
...